Robert and Jessica, bewildered but alive, fly to safety. In the ensuing battle, the snake is ejected from the plane, but Yuri is dragged out with it, and the two fall to their deaths. Robert, Jessica, and Yuri attempt to escape on the military plane, although the snake sneaks onboard and kills one of the pilots. Meanwhile, Robert and prisoner Patricia O'Boyle, a member of the Irish Republican Army, attempt to escape, although the snake kills Patricia while Robert escapes to the surface. The snake then kills two of the prisoners, but Yuri and Jessica escape to the surface. He finds Jessica alive, and they take her in. Meanwhile, the other group led by Chechen prisoner Yuri Breshcov and his cousin Peter Yuvol who had been arrested at the beginning of the film for attempting to purchase mid-range nuclear missiles for Chechnya. During the escape, one of the prisoners, a “black hat” hacker named Kelly Mitich, attempts to save himself, only to be killed by the snake and accidentally causing another gas explosion, killing Fred. Fred releases the prisoners, and the group devises a plan to escape. Robert returns to the security room and convinces Fred to release the prisoners to help in their escape. Robert and Jessica survive and flee from the snake, but Jessica is seemingly killed. After a skirmish with the snake, a gas pipe ruptures and explodes, killing the remaining security and military members.
A soldier named McCarthy is killed by the snake while his partner Simmons is found shot dead one by one, the other personnel are also killed. The security and military personnel split up and set out to find and kill the snake whilst Robert, Jessica and Fred watch on in the control room. When they arrive at the prison, they discover a group of survivors, led be head of security Quinn and prison warden Fred Riley.
They hire paleontologist Robert Trenton and his wife Jessica to assist a military team led by Major Larsten in the search to destroy the snake. The prison sends out a distress call which is received by the United States military. The engineers’ screams can be heard as the snake begins to move further into the prison. Blood drips down from the pipes onto Poluso, causing him to stare up in confusion, just as the snake attacks him and Goodman. Jenkins is stalked and killed by the snake arriving on scene, Poluso and Goodman grumble about being woken up. Jenkins, the guard, hears a strange hissing noise in the tunnels and is sent by Sergeant Quinn, his supervisor, to investigate Jenkins, unnerved, requests backup, causing Quinn to send the engineers, Poluso and Goodman, to help him. The hole is discovered by workers and a guard is placed on it until the engineers can assess the hole and block it up. The snake chews a hole through the ice, enabling it to escape into the prison. In New Alcatraz, the world's most secure prison located in Antarctica, a drilling operation inadvertently releases a giant boa constrictor from a large, hollow rock that had been preserving it in suspended animation.
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